Executive Director, Global Manufacturing Lead

Das ist der Job

Our success is driven by our people.

Darum lohnt es sich

Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality.

We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Position Summary Owns global manufacturing strategy, capacity outlook, and performance management across external CMOs. Establishes network governance routines (KPIs, performance reviews, escalation paths) to drive predictable execution aligned to demand, inventory strategy, and launch timelines.

Partners with Quality to support compliant execution and sustained inspection readiness and coordinates resolution of supply-impacting quality events. Aligns with CMC / MSAT on tech transfers, process changes, and validation readiness so technical deliverables support on‑time supply.

Sponsors continuous improvement across reliability, yield, cycle time, and cost. Key Responsibilities Network Strategy, Capacity & Performance: Own network capacity outlook and performance cadence across sites / CMOs, drive corrective actions for gaps.

Align manufacturing priorities to supply plans, inventory targets, and launch / cutover commitments. Produce deliverables such as network capacity reviews, performance scorecards, and recovery plans.

Compliance & Technical Readiness: Partner with Quality to maintain compliant execution and inspection readiness, coordinate responses to supply‑impacting quality events. Coordinate with CMC / MSAT on transfers, changes, and validation dependencies, elevate risks to milestones.

Produce deliverables such as readiness trackers and cross‑functional risk / decision packs. Continuous Improvement & Best Practice Scaling: Sponsor CI initiatives (yield, cycle time, reliability, cost) and scale effective practices across the network. Ensure consistent KPI definitions and reporting to enable comparable performance management.

Produce deliverables such as CI charters, KPI definitions, and best‑practice playbooks.

Required Qualifications BS+ (Engineering, Physical Science, Supply Chain, or related) 18+ years manufacturing / network leadership with site / CMO governance experience Demonstrated experience managing capacity constraints and performance recovery in complex networks Preferred Qualifications Experience in pharmaceutical / biotech GMP manufacturing and external manufacturing models (preferred) Experience leading launch readiness governance and multi‑site / CMO tech transfer coordination Key Competencies Manufacturing network governance, capacity strategy, and performance management, KPI cadence and corrective action leadership Partner governance and performance management across CMOs, escalation paths, accountability, and on‑time recovery Cross‑functional leadership, escalation, and executive‑ready risk / decision communication GMP‑aware operational decision‑making and inspection readiness alignment with Quality and site partners Continuous improvement (yield, reliability, cycle time) and scaling best practices across a network Equal Employment Opportunity We are committed to fostering an inclusive and diverse workplace and do not discriminate on the basis of any legally protected characteristics.

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need.

Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Applicants must be authorized to work in the country of employment at the time of application. Employment terms, where applicable, will be governed by relevant collective bargaining agreements. #J-18808-Ljbffr